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Uses: FDA-approved for major depression in adults

Referrals Has she been referred to a neurologist or haematologist

If endotoxin is present, the activated enzyme cascade cleaves the substrate, producing a color change (typically yellow) whose intensity is proportional to the endotoxin concentration

Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)