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Van de Roovaart HJ, Stevens MM, Goodridge AE, Baden KR, Sibbitt BG, Delaney E, et al

Under normal conditions, the spinal canal typically provides sufficient space for the spinal cord and nerves to move without compression

10.1016/j.ijpharm.2021.120531 186 WuchnerK.YiL.CheryC.NikelsF.JungeF.CrottsG.et al (2022a)

Human clinical-trial data (Phase 1/2 studies in wound healing, cardiac injury, and dry eye) exist only for a different, full-length recombinant thymosin beta-4 product, not for the short synthetic fragment marketed as TB-500, so no completed published human trial has evaluated TB-500 specifically for muscle, tendon, or joint recovery