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Non-enzymatic reactions may also be responsible for the production of ROS by the reaction of oxygen with organic compounds and after cellular exposure to ionizing radiation (Valko et al., 2007) (Figure 1)
At the same time, NF-B activation assays were conducted utilizing RelA (p65) protein expression as a biomarker to determine the activation status of the NF-B signaling pathway [54]
This reciprocal association between insulin and GH and its potential implications for normal substrate metabolism was initially described by Rabinowitz & Zierler (105)
JAMA Intern Med 175:542548
