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Specifically, the increased loss of RBCs leads to the increased formation of bilirubin, which further triggers eryptosis by enhancing both Ca 2+ influx, SMase activation, and ceramide production, thus creating a vicious cycle
Therefore, glutathione/glutathione disulfide concentrations and NADPH oxidase activity maintain the redox state and control mitochondrial ROS production (23)
Aisen et al , 2011
Oct 10 2002;101(5):461-468
