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Therefore, it is necessary to understand how a variety of intrinsic and extrinsic factors are integrated to create the metabolic flexibility and to reduce the metabolic dependencies dictated by oncogenic signaling

In fact, Liu et al.[172] showed that in rats fed with a high- 3 fatty acid diet there is an increase of insulin binding to sarcolemma due to changes of the fatty acyl composition of phospholipids surrounding the insulin receptor

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