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Cells synthesize glutathione in the cytosol, rather than on ribosomes, and binding of the amino group of cysteine to the - rather than to the -carboxyl group of glutamic acid makes the bond inert towards peptidases

G6PD-deficient variants that do not result in CNSHA are designated class II or class III, depending on the severity of the reduction in enzyme activity in red blood cells

Studies have reported that in patients with severe IUA, the recurrence rate can reach up to 62.5% after surgery, primarily due to persistent fibrosis and insufficient angiogenesis during endometrial repair

In: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects