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An interesting study addressing this issue showed that patients with major depression that included psychosis had more differentially expressed proteins associated with energy metabolism, whereas patients with depression without psychosis had changes in proteins associated with cell growth and maintenance, although 53.7% of the altered proteins overlapped ( That alterations in mitochondria bioenergetics pathways contributed to the pathophysiology of depression also raise the possibility of developing mitochondrial biomarkers that can illustrate a better therapeutic approach to the treatment of depression

Hydroxyl radical (OH) directly generated from the Fenton reaction abstracts a hydrogen from PUFAs, forming a phospholipid carbon-centered radical (PL), and proceeding with the oxygen addition to peroxyl radical (PL-OO) to yield a phospholipid hydroperoxide (PL-OOH)