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This positive feedback regulatory loop mechanism causes antioxidant protection in the brain [75]

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doi: 10.1034/J.1399-3038.2002.00010.X 236 RosenlundHMagnussonJKullIHkanssonNWolkAPershagenGet al

NLK protein is known to be an activator of Wnt/PCP signaling as well as the inhibitor of canonical Wnt pathway (Katoh, 2005, Katoh 2003, Wu and Maniatis, 1999)
