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Description
7.6 Anthraquinones: dual modulators of lipogenesis and antioxidant defense Anthraquinones alleviate ALD by suppressing the AMPK/SREBP-1c axis to inhibit de novo lipogenesis and activating the Nrf2/ARE pathway to upregulate antioxidant enzymes such as GST and GR ( Purpurin, an anthraquinone from the roots of Rubia tinctorum L

Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE

[1] [13] The most frequently reported adverse effects were gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation

Interestingly, EAAT3 mRNA levels were also upregulated following CSE and NNK stimulation (Fig