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Core manifestations include bradykinesia, resting tremor, and muscular rigidity, but non-motor symptoms (such as constipation, hyposmia, depression, cognitive decline, and sleep disturbances) also significantly impact quality of life (150)

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At present, the choice of mucolytic agents is based upon macroscopic examination of mucus consistency and colour, clinician experience, patient tolerance, local guidelines, and formulary restrictions

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