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This decline is called somatopause, and it contributes to many age-related changes: loss of muscle mass, increased body fat, decreased bone density, impaired cognitive function, reduced skin elasticity, and weakened immune response
The Journal of Organic Chemistry

Wu, and Manfred Boehm

Arribat et al., (2019) demonstrated in mice that the epigenetic influence of the additional copies of mtDNA on the nuclear DNA (nDNA) resulted in the cardiac abnormalities highlighting the tight regulation of mitochondrial quality control and the organelle-organ communication [28]
