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27 Subsequent structural optimization of 4 led to the identification of JBSNF-000265 ( 5 ) with an IC 50 value of 0.58 0.07 M, displaying a 3-fold improvement in activity with a favorable pharmacokinetic profile
For this reason, patients with Parkinsons disease on levodopa therapy should avoid high B intake unless they are also taking carbidopa (which prevents this interaction)
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