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In 3-AR knockout mice, chronic hGH and AOD-9604 failed to produce the body-weight change and the increase in lipolysis seen in wild-type controls establishing that the 3-AR is necessary for the sustained, chronic effect
Most protocols run 5 days on, 2 days off, in cycles of 4 to 12 weeks
Monique Sensenbrenner at a French lab and Gertrude Lindler at a German lab both demonstrated this effect in cell cultures, providing cross-laboratory validation of the nerve growth-promoting properties
