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Vincent Poitout, Email: [email protected]

Abbreviations ACC: Acetyl-CoA carboxylase CD36: Cluster of differentiation 36 CKD: Chronic kidney disease CoA: Acyl coenzyme A CPT1A: Carnitine palmitoyltransferase 1 DN: Diabetic nephropathy ECM: Extracellular matrix EMT: Epithelialmesenchymal transition ESRD: End-stage renal disease ESRRA: Estrogen-related receptor alpha FAO: Fatty acid oxidation FAS: Fatty acid synthase MF: Myofibroblasts PGC-1: Peroxisome proliferator-activated receptor coactivator 1 PPAR: Peroxisome proliferator-activated receptor RF: Renal fibrosis SCFAs: Short-chain fatty acids SIRT1: Sirtuin 1 STAT6: Signal transducer and activator of transcription 6 TCM: Traditional Chinese medicine TWIST1: Twist-related protein 1 References Djudjaj S, Boor P

But with increasing antibiotic resistance, they may not be effective in the future

Class: ACTH fragment analog (melanocortin derivative) Often referenced as ACTH(47)PGP / ACTH(410) analog in the literature Sequence: MetGluHisPheProGlyPro Molecular formula / MW: CHNOS , ~ 813.9 g/mol More stable variant commonly discussed: N-acetyl Semax (N-terminal acetylation