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Comprehensive studies on the excitation state, fluorescence spectrum and maximal intensity of curcumin in different solvents, micro-heterogeneous systems and bio-mimetic systems showed high sensitivity and dependency towards the nature of solvents [63, 68, 69]

Apart from A accumulation, microglia-induced oxidative stress can activate the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, leading to the release of mature interleukin-1 beta (IL-1 ) and interleukin-18 (IL-18) 132

10.2147/JIR.S527764 92 WeiM.MaH

Environmental toxins and pesticides exacerbate the pathological process by triggering ferroptosisa form of iron-dependent cell deathand contributing to synuclein aggregation