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In the placebo-controlled DREAM trial, Ramipril did not decrease T2DM or vascular disease in IFG patients

therefore, age, sex, comorbidities and severity of infection were included in the statistical model to identify differences between groups (Supplementary Table 1)

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Results Identification of HK2 as a suppressor of TNF-induced cell death mediated by RIPK1 In our previous screening 4 , which is aimed to investigate the role of metabolic pathways in TNF-induced cell death, we found that knockdown of Hk2 sensitized primary hepatocytes to cell death induced by TNF and cycloheximide (CHX), a combination known to induce caspase 8-mediated apoptosis and independent of RIPK1 kinase activity 41