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With respect to fructose metabolism, experiments have demonstrated that the consumption of alcohol, and its metabolism in the liver, can lead to glucose diversion into fructose which is a direct contributor to hepatic lipogenesis and the development of hepatic steatosis

[DOI] [PubMed] [Google Scholar] 170.Tay CT, Garrad R, Mousa A, Bahri M, Joham A, Teede H

In addition, succinic acid, the metabolic product of glycolysis, has been reported to promote the differentiation of lung myofibroblasts by stabilizing HIF-1 (Wang L

Methotrexate, on the other hand, reduces protective antioxidants like glutathione (GSH) and inhibits enzymes that scavenge free radicals, causing the liver to become more susceptible to damage (Goudarzi et al