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Each component has been chosen for its proven performance and synergistic effect within the formula
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Senescent-like microglia, in contrast, limit remyelination through SASP that involves the release of multiple inflammatory mediators, including CCL11, CXCL9, and CCL5, and increased expression of IL-2, leading to impaired remyelination in mouse models (Gross et al., 2025)
10.1016/j.nbd.2013.01.006 150 Tebartz Van ElstL.MaierS.FangmeierT.EndresD.MuellerG
