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To view or add a comment, sign in Meta-analysis of 32 RCTs (4896 patients) found that pharmacological, nutraceutical, and phytopharmaceutical treatments significantly reduced cancer-related fatigue (pooled effect 0.29)
Bioessays 36 , 788797 (2014)

Dynorphin released from striatal inputs could be an autofeedback mechanism, heterosynaptic (targeting pallidal input), or directly inhibit EPN neurons (Ogura and Kita, 2002)
These effects are linked to increased fibroblast activity and improved collagen formation in skin tissue
