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[DOI] [PubMed] [Google Scholar] 52.Broca C., Varin E., Armanet M., Tourrel-Cuzin C., Bosco D., Dalle S., Wojtusciszyn A

the three most common phenotypes are: PiM (medium), PiS (slow), and PiZ (very slow) ( Severe A1AT deficiency (A1ATD) is associated with specific variants, such as Z- or S- types, which can result in the early onset and sever development of emphysema, liver disease, and, rarely, multiorgan vasculitis and necrotizing panniculitis ( A1AT is abundant in the plasma with a mean concentration of 1.3 g/L and a plasma half-life of 4-5 days

Massive parallel sequencing of the region encompassing nucleotide c.1529 of PKLR was performed on paternal genomic DNA isolated from peripheral blood, a buccal swab, urine, and semen

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