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doi: 10.1136/bmj.k601
Mast cell activation may facilitate the entry of pathogenic antibodies into the CNS by disrupting the blood-brain barrier and attracting additional immune cells into neural tissue
41,169,170 Differential diagnoses include entrapment neuropathies, infectious neuropathies, and inflammatory conditions
Of obvious relevance to our findings, GSTP1 has recently been shown to be an IL-6 target gene (Wang et al, 2010), while inhibition of GSTP1 activity by an IL-6 or IL-6 receptor mAb correlates with increased platinum (and paclitaxel) sensitivity in renal cancer cells (Mizutani et al, 1995)
