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Topical serums are the easiest entry point and work well when formulated at the right concentration

CYP isoforms not only metabolize many endogenous substances including prostaglandins, lipids, fatty acids, and steroid hormones but also metabolize (detoxify) exogenous substances including drugs Major CYP isoforms responsible for drug metabolism include: CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP1A2, CYP2E1 in in certain cases CYP2A6 and CYP2D6 Important enzymes for phase II reactions include: Glutathione-S-transferases UDP-glucuronosyl transferases Sulfotransferases N-acetyltransferases Methyltransferases and Acyltransferases

53 Studies have also demonstrated that intracellular zinc release might occur as a response to oxidative or nitrosative stress, which could lead to the release of zinc from MT, a zinc buffer protein, thereby promoting apoptotic processes