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In 2024, Chen and co-workers developed cereblon-based PROTACs that target the degradation of cyclin-dependent kinases 4 and 6 (CDK4/6)

& Tirosh, B
Vecchio LM, Meng Y, Xhima K, Lipsman N, Hamani C, Aubert I

HIF-1 inhibition promotes the efficacy of immune checkpoint blockade in the treatment of non-small cell lung cancer
