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It was first described for the treatment of PD in 1948 (9) and, due to its low cost and availability, remains the most frequently prescribed oral agent for PD (10)

the calorie deficit drives weight loss

Moreover, the experimental protocol led to reduced perceived exertion at 7 min ( p = 0.046), 8 min ( p = 0.043), 9 min ( p = 0.034), and 10 min ( p = 0.034), demonstrating that the divided-dose LC protocol may provide longer-lasting benefits in reducing exertion and enhancing performance (Fig
