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Description
Upon inhibition of caspases with zVAD, the kinase activity of RIPK1 facilitates its interaction with RIPK3 to form a RIPK1/RIPK3 complex, known as necrosome, where RIPK3 is activated and mediates the phosphorylation of MLKL to promote the execution of necroptosis 20
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[DOI] [PubMed] [Google Scholar] 10.Vikse BE, Irgens LM, Leivestad T, Skjrven R, Iversen BM
