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Pegylated liposomal doxorubicin (Doxil) for metastatic breast cancer: The Cancer Research Network, Inc., experience

[143] Similarly, accumbal G9a hyperexpression results in markedly increased histone 3 lysine residue 9 dimethylation (H3K9me2) and blocks the induction of FosB-mediated neural and behavioral plasticity by chronic drug use, [sources 12] which occurs via H3K9me2-mediated repression of transcription factors for FosB and H3K9me2-mediated repression of various FosB transcriptional targets (e.g., CDK5)

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Tronci L, Serreli G, Piras C, Frau DV, Dettori T, Deiana M, et al