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Description
The pupil diameter also affects the amount of spherical aberration, because light rays do not pass through the periphery of the lens (unless the pupil is dilated)

Methylation also contributes to maintaining genome stability and supporting normal cellular processes

R., Waage, A., Aarden, L

This may further help decipher their physiological significance, e.g., when the data on phenotypes of the mutated isoenzymes in humans may appear
