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Description
doi: 10.2337/dc13-S067
AOD 9604/MOTS-c is given as a subcutaneous injection on a provider-determined schedule
The level of H3K27me3 serves as an indirect marker of CD38/NAD/SIRT1/EZH2 axis activity, in which increased CD38 expression leads to NAD + reduction, causing SIRT1 inhibition followed by increased EZH2 acetylation and trimethylation of Lys-27 in histone 3 (H3K27me3) (30)
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