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Mn was related to PD since 1837, when it was noted that high Mn exposures caused a severe and debilitating disorder known as manganism or manganeseinduced Parkinsonism, which consists on an extra pyramidal syndrome that resembles the dystonic movements associated with parkinsonian symptoms (Couper, 2005), but it is clinically distinct from PD since patients do not respond to dopamine replacement therapies (Cook et al., 1993

Microscopically, there are no more inflammatory infiltrate, well-oriented recovered tissue of musculotendon junction appears in BPC 157 treated rats at the 28 days and 42 days