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In the Phase 3 database, the mean HbA1c increase was approximately 0.1 to 0.2 percent at 52 weeks, clinically minor for most subjects but relevant for anyone with pre-existing insulin resistance or type 2 diabetes

In vitro studies have utilized human umbilical vein endothelial cells (HUVECs) to investigate angiogenic activity, human fibroblast cultures for wound migration assays, and tendon fibroblast primary cultures to examine collagen synthesis rates

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This will also ensure that we get information about the pregnancy outcome