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Patients were identified by chart review and were divided into two subgroups: early-therapy (begun within 12 months, mean 3 months, of starting insulin) and late therapy (begun more than 12 months, mean 168 months, after starting insulin)

Accordingly, the clinical paradigm has been decisively shifted from the onesizefitsall model to a precision medicine framework, where therapeutic strategies are tailored to the patient's dominant biopsychosocial feature

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PubMed , Thier, Sandra, et al