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During acute inflammatory conditions, this increase in hemichannel activity may be beneficial for mounting an immune response to an insult, however, the prolonged release of many factors (i.e., glutamate) from astrocytes in chronic conditions may be associated with altered synaptic plasticity and memory impairments (Navarrete and Araque, 2010

More hydrophilic conjugates would be expected to display a decreased binding to plasma proteins, but published investigations suggested that a change in plasma protein binding was dependent on the polyphenol and its type and position of conjugation (5962)