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Interacts with inhibitory neurotransmission pathways: Sleep onset and maintenance rely on balanced excitatory and inhibitory neurotransmission

Evidence from human drug trials, biomarker studies, neuroimaging, and animal research indicates that abnormal DYNKOR signaling is not merely a consequence of psychosis but may actively affect the disease's development and progression, particularly under chronic stress

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10.1126/science.451610 Science Summary Keywords opioid, synaptic plasticity, receptor signal transduction, neurotransmission, glutamate, GABA Citation Reeves KC, Shah N, Muoz B and Atwood BK (2022) Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain