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Description
As discussed earlier, PRDX6 binds GPX4 through a Cys47-mediated disulfide bond, facilitating GPX4 localization to cellular membranes and enhancing lipid peroxide detoxification 100
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Vascular smooth muscle cells specific deletion of angiopoietin-like protein 8 prevents angiotensin II-promoted hypertension and cardiovascular hypertrophy
For example, sustained stimulation by inflammatory cytokines such as IL-1 and TNF-, persistent oxidative stress, and pathological iron overload states have all been shown to significantly suppress SLC7A11 expression or its transport activity (Xiao et al., 2024
