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( c ) Sum of all % abundance histone methylation marks divided by total number of histone methylation marks (31) in the indicated cells normalized to control (n = 6 technical replicates from 2 independent experiments)

These melanin-independent mechanisms provide cellular UV protection additive to the physical UV-screening function of melanin , explaining why MT-1 provides photoprotection in EPP patients where the primary clinical endpoint is protection from visible light rather than UV-induced tanning

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Lamhonwah AM, Hawkins CE, Tam C, Wong J, Mai L, Tein I

When choline or methionine is deficient, VLDL synthesis stalls, and dietary fat accumulates as hepatic steatosis regardless of caloric intake