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Basic fibroblast growth factor (bFGF) protects the blood-brain barrier by binding of FGFR1 and Activating the ERK signaling pathway after intra-abdominal hypertension and traumatic brain injury

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

By modulating angiogenesis and vascular integrity, these drugs may contribute to optimizing cerebral blood flow and nutrient delivery to neurons, thereby promoting overall brain health and potentially mitigating neurodegenerative processes

[DOI] [PMC free article] [PubMed] [Google Scholar] 273.Kass R.S., Freeman L.C