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Glutamine synthetase (GLUL) is a pivotal enzyme that catalyses the conversion of ammonium and glutamate to Gln in an endogenous synthetic process

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Specifically, ferulic acid, a phenolic compound, has been shown to improve the gut microbiota dysbiosis induced by a high-fat diet, increase the accumulation of SCFA-producing bacteria in the gut and their receptor expression, reduce the levels of endotoxin-producing bacteria and serum endotoxins, and strengthen intestinal barrier function by inhibiting the colonic TLR4/NF-B inflammatory pathway [165]

Jill James is a pioneering researcher who has demonstrated how impairments in methylation biochemistry are common in autism and how targeted nutritional support can promote clinical improvements in some individuals