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Under oxidative stress, Nrf2 translocates to the nucleus and binds to the antioxidant response element (ARE), upregulating the expression of various antioxidant genes, including SLC7A11, GPX4, and HO-1

Urine sample analysis Fasting and postprandial (0, 360 min) urine samples from the subjects were collected and promptly frozen before being sent for urinary F2-IsoP analysis using LC/MS

Emerging areas of GHK-Cu research include neuroprotection and bone regeneration