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The 5-year OS was 58% (95% CI, 4077%) for CAMPATH-1M, 68% (95% CI, 4981%) for CD34+ selection, 69% (95% CI,2392%) for CD3+/CD19+ depletion and 84% (95% CI, 6793%, p=0.01) for CD3+ TCR alpha beta/CD19+ depletion (137)

Although the role of PKC- in DMD progression is an active area of research, several studies have shown that activation of PKC- leads to muscle damage in DMD by promoting inflammatory processes, increasing oxidative stress and modifying calcium signaling within muscle fibers

In particular, it demonstrates that polymer nanoparticles with tailored physicochemical properties, such as size, shape, and surface charge, can efficiently cross the BBB

Thus, the key considerations for designing therapeutic exogenous ketones are to accommodate the food-like quantities that must be delivered, and to cope with the equimolar salt or acid load involved [25]