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Notably, as NF-B p105 also belongs to the IB protein family, previous studies have noted a remarkable increase in the activation of CD4 + T cells and a higher frequency of memory/effector T cells in mice specifically deficient for p105 compared to wild-type mice (93)

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These findings opposed other studies that suggested that dopamine increased NO production, but data from BV2 cells suggest that this could result from cytotoxicity due to the production of dopamine quinones (Beck et al., 2004) and may not be mediated by dopamine receptor signaling