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Description
The peptide mimetic DPP-4 inhibitors including vildagliptin, saxagliptin and teneligliptin, were identified by peptide-based substrate substitution experiments, while the non-peptide mimetic group such as sitagliptin, alogliptin and linagliptin, were derived from the inhibitor and initially found in random screening
The safety database, while extensive for clinical trials, represents limited duration and population diversity compared to the variability encountered in clinical practice
Adecatumumab, which has a moderate affinity to EpCAM, can target tumor cells with high EPCAM expression and reduce aggression and metastasis in patients with fewer side effects [194]
Significant instability
