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After mutation of the PAZ RNA-binding pocket (F294A, Y311A), trigger variants with longer internal loops induced binding and polyubiquitylation no better than did the seed-only variant, supporting the idea that together, trigger-specific RNA trajectory and binding of the vacated PAZ pocket substantially contribute to ZSWIM8 selectivity for TDMD substrates

Thiazolidinedione (TZD) compounds, such as rosiglitazone (ROSI), pioglitazone (PIO), and troglitazone (TRO), reduced the mortality of mice after GPX4 was loss by inhibiting the action of ACSL4, indicating that these compounds may show potential therapeutic effects on AKI [43, 48]

Mutations of the cardiac ryanodine receptor ( RyR2 ) gene in familial polymorphic ventricular tachycardia

--- What Could Actually Change Scenario 1: Revised Bulk Drug Substance List The most likely near-term change is FDA updating its list of approved bulk drug substances for compounding