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[DOI] [PubMed] [Google Scholar] 67.Howden R., Andersen C.R., Goldsbrough P.B., Cobbett C.S
Tryptophan-derived indole- 3-pyruvic acid (I3P) inhibits ferroptosis by directly scavenging free radicals and activating the expression of antioxidant genes [122], suggesting that aromatic amino acid metabolism may be an important pathway for regulating ferroptosis in tumor cells [123]
Though precisely how RagA/B-mTORC1 senses cyst(e)ine levels and how mTORC1 specifically regulates GPX4 protein synthesis remain to be fully characterized
Zhou P, et al
