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Proc Natl Acad Sci USA 94:75317536 Huot P, Johnston TH, Fox SH, Newman-Tancredi A, Brotchie JM (2015) The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

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SIRT1, the most widely studied sirtuin, is recognised for its role in transcriptional regulation, genomic silencing, and epigenetic elements within the nucleus, while also contributing to metabolism and nutrient perception in the cytosol [21]

OXIDATIVE STRESS Oxidation in the outside world is the chemical mechanism that causes rust
