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2.8 IATA development considerations with respect to chemical selection across the GOLIATH metabolic disruption test methods As indicated in the methods section 2, this chemical selection was developed to support the design and development of a conceptual IATA for metabolic disruption, with specific reference chemicals for each PPAR and PPAR transactivation test method, and the WAT adipogenesis test method, but also to selectively probe each one of the three test methods, as well as consideration of the heterodimerisation partner RXR

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In fact, the FDA has specifically approved PT-141 for treating acquired generalized HSDD in premenopausal women

1d and Supplementary Fig