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Butterbur root extract (standardized to 15% petasins) has been shown to be both safe and effective for the prevention of migraines (Diener 2004

Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials

10.1016/j.bbrc.2007.05.161 21 DemaugreF.BonnefontJ

GI problems, such as constipation and diarrhea, are also common and exacerbated by limited dietary variety and fiber intake
