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BPC-157, derived from a protective protein in gastric juice, and TB-500, a synthetic fragment of Thymosin Beta-4, have both been investigated for their potential roles in healing, tissue repair, and cellular regeneration

In this Review, the authors examine the contribution of abnormalities in the glutamatergic system to the impairments in neural plasticity that are observed in patients with mood disorders, and how this knowledge can be applied to the development of antidepressants with more rapid and sustained effects.