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Briefly, -MSH induces the release of calcium (Ca 2+ ) from endoplasmic reticulum (ER) by a phospholipase C (PLC) dependent mechanism and Ca 2+ efflux is connected with the translocation of PPAR into the nucleus, where it promotes the transcription of target genes involved in lipid metabolism, adipogenesis, maintenance of metabolic homeostasis, inflammation and anticancer effects in a variety of human tumours [45]

The peptide upregulates tyrosinase, but the enzyme requires UV-induced oxidative stress to catalyze melanin polymerization

Whrend das Arginin in der Base-Form praktisch ber einen L-Arginin-Gehalt von 100% verfgt, haben andere Formen deutlich weniger L-Arginin