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In ApoE -/- mice on a high-fat diet (HFD), TMAO supplementation significantly increased vascular plaque progression, macrophage recruitment, and CD36/pro-inflammatory cytokine expression
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These data confirm our hypothesis and demonstrate that at least 2 different organisms are required for the anaerobic catabolism of l-carnitine to TMA

CPT II deficiency in infants and children A small number of children with CPT II deficiency start showing symptoms in late infancy or early childhood
