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Glutamate may also induce intra-articular inflammatory responses and abnormal pain in OA patients by activating N-methyl-D-aspartic acid (NMDA) receptors, further advancing OA progression ( 3.3 Subchondral bone remodeling and ferroptosis Subchondral bone remodeling is a hallmark pathological feature in advanced stages of OA, typically characterized by bone sclerosis and osteophyte formation
The patient must be awake with protected airway when it is used
